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Index > Protein center > Ripk1(Gene name) > Mouse
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  • Ripk1 (Gene name),
  • Receptor-interacting serine/threonine-protein kinase 1 (Protein name ),  RIPK1_MOUSE from NCBI database.
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  • Gene name:
    Ripk1(Rinp;Rip);
    Protein name:
    Receptor-interacting serine/threonine-protein kinase 1;
    Alternative:
    Receptor-interacting protein 1(RIP-1);Cell death protein RIP;Serine/threonine-protein kinase RIP;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts (via RIP homotypic interaction motif) with RIPK3 (via RIP homotypic interaction motif); this interaction induces RIPK1 necroptosis-specific phosphorylation, formation of the necroptosis-inducing complex. Interacts (via the death domain) with TNFRSF6 (via the death domain) and TRADD (via the death domain). Is recruited by TRADD to TNFRSF1A in a TNF-dependent process. Binds RNF216, EGFR, IKBKG, TRAF1, TRAF2 and TRAF3. Interacts with BNLF1. Interacts with SQSTM1 upon TNF-alpha stimulation. May interact with MAVS/IPS1. Interacts with ZFAND5. Interacts with RBCK1 (By similarity). Interacts (via RIP homotypic interaction motif) with murid herpesvirus 1 viral inhibitor of RIP activation; this interaction inhibits RIPK1 ubiquitination.
    Function:
    Serine-threonine kinase which transduces inflammatory and cell-death signals (necroptosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necroptosis-inducing complex.
    Subcellular Location:
    Cytoplasm Cell membrane
    Protein Attributes:
    Sequence length:
    656
    Sequence:
    50:
    MQPDMSLDNI | KMASSDLLEK | TDLDSGGFGK | VSLCYHRSHG | FVILKKVYTG | 
    100:
    PNRAEYNEVL | LEEGKMMHRL | RHSRVVKLLG | IIIEEGNYSL | VMEYMEKGNL | 
    150:
    MHVLKTQIDV | PLSLKGRIIV | EAIEGMCYLH | DKGVIHKDLK | PENILVDRDF | 
    200:
    HIKIADLGVA | SFKTWSKLTK | EKDNKQKEVS | STTKKNNGGT | LYYMAPEHLN | 
    250:
    DINAKPTEKS | DVYSFGIVLW | AIFAKKEPYE | NVICTEQFVI | CIKSGNRPNV | 
    300:
    EEILEYCPRE | IISLMERCWQ | AIPEDRPTFL | GIEEEFRPFY | LSHFEEYVEE | 
    350:
    DVASLKKEYP | DQSPVLQRMF | SLQHDCVPLP | PSRSNSEQPG | SLHSSQGLQM | 
    400:
    GPVEESWFSS | SPEYPQDEND | RSVQAKLQEE | ASYHAFGIFA | EKQTKPQPRQ | 
    450:
    NEAYNREEER | KRRVSHDPFA | QQRARENIKS | AGARGHSDPS | TTSRGIAVQQ | 
    500:
    LSWPATQTVW | NNGLYNQHGF | GTTGTGVWYP | PNLSQMYSTY | KTPVPETNIP | 
    550:
    GSTPTMPYFS | GPVADDLIKY | TIFNSSGIQI | GNHNYMDVGL | NSQPPNNTCK | 
    600:
    EESTSRHQAI | FDNTTSLTDE | HLNPIRENLG | RQWKNCARKL | GFTESQIDEI | 
    650:
    DHDYERDGLK | EKVYQMLQKW | LMREGTKGAT | VGKLAQALHQ | CCRIDLLNHL | 
    656:
    IRASQS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    UniGene:
    KEGG:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Receptor-interacting serine/threonine-protein kinase 1
    Cat.:
    E15191h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse Receptor-interacting serine/threonine-protein kinase 1
    Cat.:
    E15191m
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Receptor-interacting serine/threonine-protein kinase 1
    Cat.:
    U15191h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Receptor-interacting serine/threonine-protein kinase 1
    Cat.:
    U15191m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Receptor-interacting serine/threonine-protein kinase 1
    Cat.:
    P15191Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Receptor-interacting serine/threonine-protein kinase 1
    Cat.:
    P15191Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Receptor-interacting serine/threonine-protein kinase 1
    Monoclonal Antibody for Mouse Receptor-interacting serine/threonine-protein kinase 1
    Protein for Mouse Receptor-interacting serine/threonine-protein kinase 1
    Protein for Mouse Receptor-interacting serine/threonine-protein kinase 1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death."
      Stanger B.Z. , Leder P. , Lee T.-H. , Kim E. , Seed B.
      Cell81:513-523(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: C57BL/6 X CBA.
      tissue: Thymus.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      strain: NOD.
      tissue: Spleen.
      tissue: Thymus.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Brain.
      tissue: Liver.
    4. 4.
      "The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation."
      Hur G.M. , Lewis J. , Yang Q. , Lin Y. , Nakano H. , Nedospasov S. , Liu Z.G.
      Genes Dev.17:873-882(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    5. 5.
      "RIP1, a kinase on the crossroads of a cell's decision to live or die."
      Festjens N. , Vanden Berghe T. , Cornelis S. , Vandenabeele P.
      Cell Death Differ.14:400-410(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    6. 6.
      "Cytomegalovirus M45 cell death suppression requires receptor-interacting protein (RIP) homotypic interaction motif (RHIM)-dependent interaction with RIP1."
      Upton J.W. , Kaiser W.J. , Mocarski E.S.
      J. Biol. Chem.283:16966-16970(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MURID HERPESVIRUS 1 VIRAL INHIBITOR OF RIP ACTIVATION
    7. 7.
      "DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB."
      Rebsamen M. , Heinz L.X. , Meylan E. , Michallet M.C. , Schroder K. , Hofmann K. , Vazquez J. , Benedict C.A. , Tschopp J.
      EMBO Rep.10:916-922(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ZBP1
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